Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.

Vermeij, Wilbert P; Hoeijmakers, Jan H J; Pothof, Joris

Vermeij, Wilbert P; Hoeijmakers, Jan H J; Pothof, Joris.

Afiliação

Vermeij WP; Department of Genetics, Erasmus University Medical Center, Postbus 2040, 3000 CA, Rotterdam, The Netherlands; email: w.vermeij@erasmusmc.nl , j.hoeijmakers@erasmusmc.nl , j.pothof@erasmusmc.nl.
Hoeijmakers JH; Department of Genetics, Erasmus University Medical Center, Postbus 2040, 3000 CA, Rotterdam, The Netherlands; email: w.vermeij@erasmusmc.nl , j.hoeijmakers@erasmusmc.nl , j.pothof@erasmusmc.nl.
Pothof J; Department of Genetics, Erasmus University Medical Center, Postbus 2040, 3000 CA, Rotterdam, The Netherlands; email: w.vermeij@erasmusmc.nl , j.hoeijmakers@erasmusmc.nl , j.pothof@erasmusmc.nl.

Annu Rev Pharmacol Toxicol ; 56: 427-45, 2016.

Article em En | MEDLINE | ID: mdl-26514200

Assuntos

Envelhecimento/genética; Instabilidade Genômica/genética; Animais; Modelos Animais de Doenças; Humanos; Camundongos; Síndrome

Palavras-chave

DNA damage; DNA repair; age-related diseases; antiaging interventions; frailty; progeria

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Instabilidade Genômica Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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