Endosomal integrin signals for survival.

Rainero, Elena; Norman, Jim C

Rainero, Elena; Norman, Jim C.

Afiliação

Rainero E; Cancer Research UK, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
Norman JC; Cancer Research UK, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

Nat Cell Biol ; 17(11): 1373-5, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26515017

ABSTRACT

ABSTRACT

The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.

Assuntos

Anoikis/fisiologia; Endossomos/metabolismo; Quinase 1 de Adesão Focal/metabolismo; Integrina beta1/metabolismo; Transdução de Sinais/fisiologia; Animais; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endossomos / Transdução de Sinais / Integrina beta1 / Anoikis / Quinase 1 de Adesão Focal Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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