Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity.

Sapienza, Paul J; Falk, Bradley T; Lee, Andrew L

Sapienza, Paul J; Falk, Bradley T; Lee, Andrew L.

Afiliação

Sapienza PJ; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Falk BT; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Lee AL; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

J Am Chem Soc ; 137(45): 14260-3, 2015 Nov 18.

Article em En | MEDLINE | ID: mdl-26517288

Assuntos

Coenzimas/metabolismo; Escherichia coli/enzimologia; Timidilato Sintase/química; Timidilato Sintase/metabolismo; Regulação Alostérica; Sítios de Ligação; Tetra-Hidrofolatos/química; Tetra-Hidrofolatos/metabolismo; Termodinâmica; Uridina Monofosfato/análogos & derivados; Uridina Monofosfato/química; Uridina Monofosfato/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timidilato Sintase / Coenzimas / Escherichia coli Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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