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Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients.
Turay, David; Khan, Salma; Diaz Osterman, Carlos J; Curtis, Matthew P; Khaira, Balreet; Neidigh, Jonathan W; Mirshahidi, Saied; Casiano, Carlos A; Wall, Nathan R.
Afiliação
  • Turay D; a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Khan S; b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Diaz Osterman CJ; a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Curtis MP; b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Khaira B; a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Neidigh JW; b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Mirshahidi S; b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Casiano CA; b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
  • Wall NR; b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
Cancer Invest ; 34(1): 1-11, 2016.
Article em En | MEDLINE | ID: mdl-26536157
Prostate cancer (PCa) remains the most frequently diagnosed male malignancy in Western countries and the second most common cause of male cancer death in the United States. The relatively elevated PCa incidence and mortality among African American men makes this cancer type a challenging health disparity disease. To increase the chance for successful trea tment, earlier detection and prediction of tumor aggress iveness will be important and need to be resolved. This study demonstrates that small membrane-bound vesicles shed from the tumor called exosomes contain ethnically and tumor-specific biomarkers, and could be exploited for their diagnostic and therapeutic potential.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Etnicidade / Proteoma / Proteômica / Exossomos Tipo de estudo: Observational_studies / Risk_factors_studies / Screening_studies Limite: Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Etnicidade / Proteoma / Proteômica / Exossomos Tipo de estudo: Observational_studies / Risk_factors_studies / Screening_studies Limite: Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article