Importance of angina in patients with coronary disease, heart failure, and left ventricular systolic dysfunction: insights from STICH.
J Am Coll Cardiol
; 66(19): 2092-2100, 2015 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-26541919
ABSTRACT
BACKGROUND:
Patients with left ventricular (LV) systolic dysfunction, coronary artery disease (CAD), and angina are often thought to have a worse prognosis and a greater prognostic benefit from coronary artery bypass graft (CABG) surgery than those without angina.OBJECTIVES:
This study investigated 1) whether angina was associated with a worse prognosis; 2) whether angina identified patients who had a greater survival benefit from CABG; and 3) whether CABG improved angina in patients with LV systolic dysfunction and CAD.METHODS:
We performed an analysis of the STICH (Surgical Treatment for Ischemic Heart Failure) trial, in which 1,212 patients with an ejection fraction ≤35% and CAD were randomized to CABG or medical therapy. Multivariable Cox and logistic models were used to assess long-term clinical outcomes.RESULTS:
At baseline, 770 patients (64%) reported angina. Among patients assigned to medical therapy, all-cause mortality was similar in patients with and without angina (hazard ratio [HR] 1.05; 95% confidence interval [CI] 0.79 to 1.38). The effect of CABG was similar whether the patient had angina (HR 0.89; 95% CI 0.71 to 1.13) or not (HR 0.68; 95% CI 0.50 to 0.94; p interaction = 0.14). Patients assigned to CABG were more likely to report improvement in angina than those assigned to medical therapy alone (odds ratio 0.70; 95% CI 0.55 to 0.90; p < 0.01).CONCLUSIONS:
Angina does not predict all-cause mortality in medically treated patients with LV systolic dysfunction and CAD, nor does it identify patients who have a greater survival benefit from CABG. However, CABG does improve angina to a greater extent than medical therapy alone. (Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease [STICH]; NCT00023595).Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Disfunção Ventricular Esquerda
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Insuficiência Cardíaca
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Angina Pectoris
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article