Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity.

Dyer, Paul D R; Shepherd, Thomas R; Gollings, Alexander S; Shorter, Susan A; Gorringe-Pattrick, Monique A M; Tang, Chun-Kit; Cattoz, Beatrice N; Baillie, Les; Griffiths, Peter C; Richardson, Simon C W

Dyer, Paul D R; Shepherd, Thomas R; Gollings, Alexander S; Shorter, Susan A; Gorringe-Pattrick, Monique A M; Tang, Chun-Kit; Cattoz, Beatrice N; Baillie, Les; Griffiths, Peter C; Richardson, Simon C W.

Afiliação

Dyer PDR; Intercellular Delivery Solutions Laboratory, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK.
Shepherd TR; Intercellular Delivery Solutions Laboratory, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK.
Gollings AS; Intercellular Delivery Solutions Laboratory, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK.
Shorter SA; Intercellular Delivery Solutions Laboratory, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK.
Gorringe-Pattrick MAM; Intercellular Delivery Solutions Laboratory, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK.
Tang CK; Intercellular Delivery Solutions Laboratory, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK.
Cattoz BN; Department of Pharmaceutical, Chemical and Environmental Science, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.
Baillie L; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3AX, UK.
Griffiths PC; Department of Pharmaceutical, Chemical and Environmental Science, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.
Richardson SCW; Intercellular Delivery Solutions Laboratory, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK. Electronic address: S.C.W.Richardson@Greenwich.ac.uk.

J Control Release ; 220(Pt A): 316-328, 2015 Dec 28.

Article em En | MEDLINE | ID: mdl-26546271

Assuntos

Antígenos de Bactérias/genética; Toxinas Bacterianas/genética; Técnicas de Silenciamento de Genes; Oligonucleotídeos Antissenso/genética; Interferência de RNA; RNA Interferente Pequeno/genética; Transfecção/métodos; Animais; Antígenos de Bactérias/metabolismo; Toxinas Bacterianas/metabolismo; Chlorocebus aethiops; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Regulação da Expressão Gênica; Células HeLa; Humanos; Oligonucleotídeos Antissenso/biossíntese; Proteínas Qa-SNARE/biossíntese; Proteínas Qa-SNARE/genética; RNA Interferente Pequeno/metabolismo; Proteínas Recombinantes de Fusão/genética; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo; Fatores de Tempo; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Células Vero; eIF-2 Quinase/genética; eIF-2 Quinase/metabolismo

Palavras-chave

Anthrax toxin; Antisense; Non-viral; PEG-dilemma; RNAi

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Bacterianas / Transfecção / Oligonucleotídeos Antissenso / RNA Interferente Pequeno / Interferência de RNA / Técnicas de Silenciamento de Genes / Antígenos de Bactérias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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