Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.

Wojtuszkiewicz, Anna; Raz, Shachar; Stark, Michal; Assaraf, Yehuda G; Jansen, Gerrit; Peters, Godefridus J; Sonneveld, Edwin; Kaspers, Gertjan J L; Cloos, Jacqueline

Wojtuszkiewicz, Anna; Raz, Shachar; Stark, Michal; Assaraf, Yehuda G; Jansen, Gerrit; Peters, Godefridus J; Sonneveld, Edwin; Kaspers, Gertjan J L; Cloos, Jacqueline.

Afiliação

Wojtuszkiewicz A; Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Raz S; Department Of Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Stark M; Department Of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Assaraf YG; Department Of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Jansen G; Department Of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Peters GJ; Department Of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands.
Sonneveld E; Department Of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Kaspers GJ; Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands.
Cloos J; Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.

Int J Cancer ; 138(7): 1645-56, 2016 Apr 01.

Article em En | MEDLINE | ID: mdl-26547381

Assuntos

Antineoplásicos/uso terapêutico; Resistencia a Medicamentos Antineoplásicos/fisiologia; Metotrexato/uso terapêutico; Peptídeo Sintases/metabolismo; Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico; Leucemia-Linfoma Linfoblástico de Células Precursoras/enzimologia; Adulto; Processamento Alternativo; Western Blotting; Criança; Feminino; Citometria de Fluxo; Humanos; Masculino; Reação em Cadeia da Polimerase em Tempo Real; Reação em Cadeia da Polimerase Via Transcriptase Reversa

Palavras-chave

acute lymphoblastic leukemia; alternative splicing; drug resistance; folylpolyglutamate synthetase; methotrexate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Sintases / Metotrexato / Resistencia a Medicamentos Antineoplásicos / Leucemia-Linfoma Linfoblástico de Células Precursoras / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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