Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants.
Tetrahedron
; 71(44): 8444-8453, 2015 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-26549895
ABSTRACT
A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article