Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic &#945;-cells.

Elrick, Mollisa M; Samson, Willis K; Corbett, John A; Salvatori, Alison S; Stein, Lauren M; Kolar, Grant R; Naatz, Aaron; Yosten, Gina L C

Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.

Elrick, Mollisa M; Samson, Willis K; Corbett, John A; Salvatori, Alison S; Stein, Lauren M; Kolar, Grant R; Naatz, Aaron; Yosten, Gina L C.

Afiliação

Elrick MM; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri;
Samson WK; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri;
Corbett JA; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin.
Salvatori AS; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri;
Stein LM; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri;
Kolar GR; Department of Pathology, Saint Louis University School of Medicine, St. Louis, Missouri; and.
Naatz A; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin.
Yosten GL; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri; gyosten@slu.edu.

Am J Physiol Regul Integr Comp Physiol ; 310(2): R143-55, 2016 Jan 15.

Article em En | MEDLINE | ID: mdl-26561648

Assuntos

Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; AMP Cíclico/metabolismo; Células Secretoras de Glucagon/efeitos dos fármacos; Hormônios Peptídicos/farmacologia; Proglucagon/genética; RNA Mensageiro/genética; Receptores Acoplados a Proteínas G/agonistas; Animais; Linhagem Celular; Células Secretoras de Glucagon/enzimologia; Humanos; Masculino; Camundongos; Fragmentos de Peptídeos/metabolismo; Hormônios Peptídicos/metabolismo; Fosforilação; Interferência de RNA; Ratos Sprague-Dawley; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Transdução de Sinais/efeitos dos fármacos; Somatostatina/metabolismo; Transfecção; Regulação para Cima

Palavras-chave

GPR107; cAMP-independent PKA activation; glucagon; glucose homeostasis; islet function; neuronostatin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Proteínas Quinases Dependentes de AMP Cíclico / AMP Cíclico / Hormônios Peptídicos / Receptores Acoplados a Proteínas G / Células Secretoras de Glucagon / Proglucagon Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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