Expression and Function of CD44 in Epithelial Ovarian Carcinoma.

Sacks, Joelle D; Barbolina, Maria V

Sacks, Joelle D; Barbolina, Maria V.

Afiliação

Sacks JD; Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA. jsacks3@uic.edu.
Barbolina MV; Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA. mvb@uic.edu.

Biomolecules ; 5(4): 3051-66, 2015 Nov 11.

Article em En | MEDLINE | ID: mdl-26569327

ABSTRACT

ABSTRACT

CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed.

Assuntos

Carcinoma/metabolismo; Receptores de Hialuronatos/metabolismo; Neoplasias Ovarianas/metabolismo; Animais; Carcinoma/genética; Carcinoma/terapia; Feminino; Humanos; Receptores de Hialuronatos/genética; Células-Tronco Neoplásicas/metabolismo; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/terapia; Processamento de Proteína Pós-Traducional

Palavras-chave

CD44; adhesion; cancer stem cells; epithelial ovarian carcinoma; hyaluronan; metastasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Carcinoma / Receptores de Hialuronatos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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