4E-BP1, eukaryotic translation initiation factor 4E (eIF-4E) binding protein p70 S6 kinase (S6K); ADM, adrenomedullin; AKt, protein kinase B; ARD-1, arrest-defective-1; ARNT, aryl hydrocarbon nuclear translocator; AhR, aryl hydrocarbon receptor; C-MYC, myelocytomatosis virus oncogene cellular homolog; C-TAD, COOH-terminal TAD; CAC, circulating angiogenic cells; CPTs, camptothecins; Cancer drug discovery and development; ChIP, chromatin immunoprecipitation; CoCl2, cobalt chloride; DFO, deferoxamine; EGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; EMSA, electrophoretic mobility shift assay; EPO, erythropoietin; ERK, extracellular signal-regulated kinase; FIH-1, factor inhibiting HIF-1; GA, geldanamycin; GAs, geldanamycins; GLUT1, glucose transporter 1; GLUT3, glucose transporter 3; GLUTs, glucose transporters; HDAC, histone deacetylase; HIF-1α; HIF-1α inhibitors; HIF-1α, hypoxia-inducible factor-1α; HK1, hexokinase 1; HK2, hexokinase 2; HPH, HIF-1 prolyl hydroxylases; HRE, hypoxia response elements; HTS, high throughput screens; Hsp90, heat shock protein 90; ID2, DNA-binding protein inhibitor; IGF-BP2, IGF-factor-binding protein 2; IGF-BP3, IGF-factor-binding protein 3; IGF2, insulin-like growth factor 2; IPAS, inhibitory PAS; K, lysine residue; LDHA, lactate dehydrogenase; LEP, leptin; LRP1, LDL-receptor-related protein 1; Luc, luciferase; MAPK, mitogen-activated protein kinases; MEK, MAPK/ERK kinase; MNK, MAP kinase interacting kinase; MTs, microtubules; Mdm2, mouse double minute 2 homolog; N, asparagine residue; N-TAD, NH2-terminal TAD; NOS, nitric oxide synthase; ODDD, oxygen dependent degradation domain; P, proline residue; PAS, Per and Sim; PCAF, p300/CBP associated factor; PHDs, prolyl-4-hydroxylases; PI3K, phosphatidyl inositol-4,5-bisphosphate-3-kinase; PKM, pyruvate kinase M; RCC, renal cell carcinoma; RT-PCR, reverse transcription polymerase chain reaction; Raf, rapidly accelerated fibrosarcoma; Ras, rat sarcoma; SIRT 1, Sirtuin 1; TAD, transactivation domains; TGF-α, transforming growth factor α; TGF-ß3, transforming growth factor beta3; TPT, topotecan; Top I, topoisomerase I; VEGF, vascular endothelial growth factor; bHLH, basic-helix-loop-helix; eIF-4E, eukaryotic translation initiation factor 4E; mTOR, mammalian target of rapamycin; pVHL, von Hippel-Lindau protein