From analysis to synthesis: new ligand binding sites on the lactate dehydrogenase framework. Part I.
Trends Biochem Sci
; 14(3): 101-5, 1989 Mar.
Article
em En
| MEDLINE
| ID: mdl-2658216
ABSTRACT
In Part I of this article, the naturally evolved protein framework of lactate dehydrogenase is investigated by genetically introduced modifications which reveal the structural basis of its catalytic and substrate-binding properties. In Part II (to be published in the April issue of TIBS), this analytical information is exploited in the design of two modified forms of the enzyme; one which is specific for a new substrate and one which lacks allosteric regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
L-Lactato Desidrogenase
/
Ligantes
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article