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BODIPY-Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models.
Lee, Hoyeon; Yang, Zhigang; Wi, Youngjin; Kim, Tae Woo; Verwilst, Peter; Lee, Yun Hak; Han, Ga-In; Kang, Chulhun; Kim, Jong Seung.
Afiliação
  • Lee H; The School of East-West Medical Science, Kyung Hee University , Yongin 446-701, Korea.
  • Yang Z; Department of Chemistry, Korea University , Seoul 136-701, Korea.
  • Wi Y; The School of East-West Medical Science, Kyung Hee University , Yongin 446-701, Korea.
  • Kim TW; The School of East-West Medical Science, Kyung Hee University , Yongin 446-701, Korea.
  • Verwilst P; Department of Chemistry, Korea University , Seoul 136-701, Korea.
  • Lee YH; Department of Chemistry, Korea University , Seoul 136-701, Korea.
  • Han GI; The School of East-West Medical Science, Kyung Hee University , Yongin 446-701, Korea.
  • Kang C; The School of East-West Medical Science, Kyung Hee University , Yongin 446-701, Korea.
  • Kim JS; Department of Chemistry, Korea University , Seoul 136-701, Korea.
Bioconjug Chem ; 26(12): 2474-80, 2015 Dec 16.
Article em En | MEDLINE | ID: mdl-26588433
ABSTRACT
An endoplasmic reticulum (ER) membrane-selective chemosensor composed of BODIPY and coumarin moieties and a long alkyl chain (n-C18) was synthesized. The emission ratio of BODIPY to coumarin depends on the solution viscosity. The probe is localized to the ER membrane and was applied to reveal the reduced ER membrane fluidity under ER stress conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Boro / Cumarínicos / Retículo Endoplasmático / Estresse do Retículo Endoplasmático / Corantes Fluorescentes / Fluidez de Membrana Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Boro / Cumarínicos / Retículo Endoplasmático / Estresse do Retículo Endoplasmático / Corantes Fluorescentes / Fluidez de Membrana Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article