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Evaluating 5-Nitrothiazoles as Trypanocidal Agents.
O'Shea, Ivan P; Shahed, Mohammed; Aguilera-Venegas, Benjamín; Wilkinson, Shane R.
Afiliação
  • O'Shea IP; School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom.
  • Shahed M; School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom.
  • Aguilera-Venegas B; Laboratory of Antioxidants, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
  • Wilkinson SR; School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom s.r.wilkinson@qmul.ac.uk.
Antimicrob Agents Chemother ; 60(2): 1137-40, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26596950
ABSTRACT
The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocyclic drugs may represent a new lead in the treatment of human African trypanosomiasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Tripanossomicidas / Trypanosoma brucei brucei Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Tripanossomicidas / Trypanosoma brucei brucei Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article