Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort.
Alzheimers Dement
; 12(3): 281-91, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26602629
ABSTRACT
INTRODUCTION:
Few studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle-aged individuals.METHODS:
We included 464 cognitively normal, test-naïve, participants with Pittsburgh compound B positron emission tomography amyloid imaging, mean age of 62.7 (range, 51-71 years), enrolled in the Mayo Clinic Study of Aging. Participants completed multiple cognitive assessments, including a standard neuropsychological battery and the CogState computerized battery, over 30 months of follow-up. Linear mixed models were used to examine the effects of amyloid and APOE genotype on baseline cognition and cognitive decline.RESULTS:
Elevated amyloid was not associated with tests of episodic memory but did predict declines on tests of executive function. APOE genotype was not associated with cognition. Among APOE É4 noncarriers, higher amyloid was predictive of decline on tests of executive function and on one episodic memory test.DISCUSSION:
Elevated amyloidosis and APOE genotype do not appear to exert a dramatic influence on cognition in middle age.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
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Peptídeos beta-Amiloides
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Cognição
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Amiloidose
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article