Synthesis, crystal structure, DNA and protein binding studies of novel binuclear Pd(II) complex of 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone.
J Inorg Biochem
; 155: 1-8, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26606287
ABSTRACT
A novel binuclear palladium(II) complex [(AsPh3)2ClPd(L)PdCl] (LPd2) has been synthesized by reacting 2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone (HL) with [PdCl2(AsPh3)2], and the molecular structure was confirmed by single crystal X-ray diffraction studies. The DNA interactions of the free ligand and of the complex have been evaluated by absorption and ethidium bromide (EB) competitive studies which revealed that the complex could interact with calf thymus DNA (CT-DNA) through intercalation. In addition, the interactions with bovine serum albumin (BSA) were also studied showing that the new binuclear palladium complex had a strong binding affinity with BSA.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paládio
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Tiossemicarbazonas
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DNA
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Proteínas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article