Improved bioavailability of targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiac microenvironment.

Ray, Aramita; Rana, Santanu; Banerjee, Durba; Mitra, Arkadeep; Datta, Ritwik; Naskar, Shaon; Sarkar, Sagartirtha

Ray, Aramita; Rana, Santanu; Banerjee, Durba; Mitra, Arkadeep; Datta, Ritwik; Naskar, Shaon; Sarkar, Sagartirtha.

Afiliação

Ray A; Genetics and Molecular Cardiology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: aramitaray@yahoo.co.in.
Rana S; Genetics and Molecular Cardiology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: rana.santanu@gmail.com.
Banerjee D; Genetics and Molecular Cardiology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: durba.research@gmail.com.
Mitra A; Genetics and Molecular Cardiology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: arkadeep.mitra@gmail.com.
Datta R; Genetics and Molecular Cardiology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: rdatta30@gmail.com.
Naskar S; Genetics and Molecular Cardiology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: shaon.me@gmail.com.
Sarkar S; Genetics and Molecular Cardiology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: sagartirtha.sarkar@gmail.com.

Toxicol Appl Pharmacol ; 290: 54-65, 2016 Jan 01.

Article em En | MEDLINE | ID: mdl-26612707

Assuntos

Apoptose/efeitos dos fármacos; Cardiomegalia/tratamento farmacológico; Curcumina/farmacocinética; Sistemas de Liberação de Medicamentos; Acetilação; Animais; Disponibilidade Biológica; Caspase 3/genética; Caspase 3/metabolismo; Sobrevivência Celular/efeitos dos fármacos; Quitosana/análogos & derivados; Quitosana/química; Curcumina/administração & dosagem; Citocromos c/genética; Citocromos c/metabolismo; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Regulação para Baixo; Proteína p300 Associada a E1A/genética; Proteína p300 Associada a E1A/metabolismo; Miocárdio/patologia; Miócitos Cardíacos/efeitos dos fármacos; Nanopartículas/química; Ratos; Ratos Wistar; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Proteína X Associada a bcl-2/genética; Proteína X Associada a bcl-2/metabolismo

Palavras-chave

Cardiac hypertrophy; Cardiomyocyte apoptosis; Cardiomyocyte targeted delivery; Curcumin; p53 ubiquitination; p53p300 interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Apoptose / Cardiomegalia / Curcumina Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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