[Hemoglobin variants in Colombian patients referred to discard hemoglobinopathies]. / Variantes de hemoglobina en una población con impresión diagnóstica positiva para hemoglobinopatías en Colombia.
Rev Med Chil
; 143(10): 1260-8, 2015 Oct.
Article
em Es
| MEDLINE
| ID: mdl-26633269
ABSTRACT
BACKGROUND:
Oxygen transport is altered in hemoglobinopathies.AIM:
To study the distribution of hemoglobinopathies in Andean subjects without African ancestry. MATERIAL ANDMETHODS:
We analyzed blood samples of 1,407 subjects aged 18 to 59 years (58% females), living in the central Andean region of Colombia, referred to discard hemoglobinopathies. The frequency and type of hemoglobinopathy was established by capillary and agarose gel electrophoresis.RESULTS:
The frequency of hemoglobinopathies was 34.5% and higher among females. The structural variants found were AS-heterozygous hemoglobin (8.1%), homozygous SS (3.7%), heterozygous SC (2.2%), AC heterozygotes (0.5%) and heterozygous AE (0.3%). Quantitative variants found were Hb A-Beta thalassemia (13.91%) and Hb H (0.06%), Beta-thalassemia heterozygotes C (0.88%), S-Beta thalassemia heterozygotes (6.07%) and compound heterozygous SC/Beta thalassemia (0.25%), with a persistence of fetal hemoglobin 0. Composite thalassemia was also found in 31%. All techniques showed good correlation and capillary electrophoresis demonstrated a greater detection of hemoglobin variants.CONCLUSIONS:
The frequency of hemoglobin variants in the analyzed population was high, which is an important public health indicator. The most common hemoglobin variant was HbA/Increased structural Hb A2 and the mos frequent structural hemoglobinopathy was sickle cell trait. Capillary electrophoresis can discern any Hb variants present in the population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas
/
Hemoglobinopatias
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Colombia
Idioma:
Es
Ano de publicação:
2015
Tipo de documento:
Article