Cerebrospinal Fluid Anti-Amyloid-ß Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation.
J Alzheimers Dis
; 50(1): 1-7, 2016.
Article
em En
| MEDLINE
| ID: mdl-26639966
ABSTRACT
We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aß autoantibodies, t-Tau, and p-Tau and decreased Aß40 and Aß42. After treatment, focal symptomatology disappeared, and WML and anti-Aß autoantibodies decreased. The APOEÉ4 allele was overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aß autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Peptídeos beta-Amiloides
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Angiopatia Amiloide Cerebral
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article