Your browser doesn't support javascript.
loading
Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice.
Bi, Yuhai; Xiao, Haixia; Chen, Quanjiao; Wu, Yan; Fu, Lifeng; Quan, Chuansong; Wong, Gary; Liu, Jun; Haywood, Joel; Liu, Yingxia; Zhou, Boping; Yan, Jinghua; Liu, Wenjun; Gao, George F.
Afiliação
  • Bi Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China Center for Influenza Research and Early Warning (CASCIRE), Chinese
  • Xiao H; Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China.
  • Chen Q; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei, China Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China.
  • Wu Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Fu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Quan C; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
  • Wong G; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Liu J; Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
  • Haywood J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Liu Y; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China.
  • Zhou B; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China.
  • Yan J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Liu W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China.
  • Gao GF; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China Laboratory of Protein Engineering and Vaccines, Tianjin Institute o
J Virol ; 90(4): 2142-9, 2016 02 15.
Article em En | MEDLINE | ID: mdl-26656694
The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Infecções por Orthomyxoviridae / Fatores de Virulência / Subtipo H7N9 do Vírus da Influenza A / Neuraminidase Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Infecções por Orthomyxoviridae / Fatores de Virulência / Subtipo H7N9 do Vírus da Influenza A / Neuraminidase Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article