Biological modeling of mucus to modulate mucus barriers.

Desseyn, Jean-Luc; Gouyer, Valérie; Gottrand, Frédéric

Desseyn, Jean-Luc; Gouyer, Valérie; Gottrand, Frédéric.

Afiliação

Desseyn JL; LIRIC-UMR 995, Inserm, University of Lille, Lille, France jean-luc.desseyn@inserm.fr.
Gouyer V; LIRIC-UMR 995, Inserm, University of Lille, Lille, France.
Gottrand F; LIRIC-UMR 995, Inserm, University of Lille, Lille, France.

Am J Physiol Gastrointest Liver Physiol ; 310(4): G225-7, 2016 Feb 15.

Article em En | MEDLINE | ID: mdl-26660538

ABSTRACT

ABSTRACT

A recent study using a transgenic mouse, whose intestinal mucus contains a molecule made of 12 copies of a domain found in many gelling mucins, demonstrates that it is possible to strengthen mucus properties in situ, leading to promising new treatment strategies in diseases in which the mucosal barrier is impaired.

Assuntos

Microbioma Gastrointestinal/imunologia; Mucosa Intestinal/metabolismo; Mucina-2/metabolismo; Muco/metabolismo; Junções Íntimas/fisiologia; Animais

Palavras-chave

gelling mucin; mucin CYS domain; mucosal barrier; mucus; transgenic mouse

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Junções Íntimas / Mucina-2 / Microbioma Gastrointestinal / Mucosa Intestinal / Muco Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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