L-3-n-Butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and upregulating Heme oxygenase-1 in lipopolysaccharide-treated mice.

Zhao, Chun-Yang; Lei, Hui; Zhang, Yu; Li, Lin; Xu, Shao-Feng; Cai, Jie; Li, Ping-Ping; Wang, Ling; Wang, Xiao-Liang; Peng, Ying

Zhao, Chun-Yang; Lei, Hui; Zhang, Yu; Li, Lin; Xu, Shao-Feng; Cai, Jie; Li, Ping-Ping; Wang, Ling; Wang, Xiao-Liang; Peng, Ying.

Afiliação

Zhao CY; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Lei H; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Zhang Y; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Li L; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Xu SF; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Cai J; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Li PP; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Wang L; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Wang XL; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
Peng Y; a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.

J Asian Nat Prod Res ; 18(3): 289-302, 2016.

Article em En | MEDLINE | ID: mdl-26675131

Assuntos

Benzofuranos/farmacologia; Heme Oxigenase-1/metabolismo; Lipopolissacarídeos/farmacologia; Animais; Encéfalo/efeitos dos fármacos; Citocinas/metabolismo; Modelos Animais de Doenças; Fatores Imunológicos/farmacologia; Inflamação/tratamento farmacológico; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Camundongos; Camundongos Endogâmicos C57BL; Microglia/efeitos dos fármacos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Estrutura Molecular; Fármacos Neuroprotetores/farmacologia; Fosforilação/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Fator de Necrose Tumoral alfa; Regulação para Cima/efeitos dos fármacos

Palavras-chave

JNK; L-3-n-butylphthalide; lipopolysaccharide; neuroinflammatory response

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Lipopolissacarídeos / Heme Oxigenase-1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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