Synthesis and oral hypoglycemic properties of two 4-oxo-4,5,6,7-tetrahydroindole-3-acetic acids.
Arzneimittelforschung
; 39(5): 548-50, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2667524
ABSTRACT
Condensation of beta-acetyl-2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexene-1-propionic acid (3) with n-butyl and isobutylamines affords the title acids 4 and 5, respectively, which show good oral hypoglycemic activity in normal rats. Acids 4 and 5, are also active in streptozocin-induced diabetic rats. Results of extensive pharmacological and acute toxicity tests are reported.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipoglicemiantes
/
Ácidos Indolacéticos
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article