The long noncoding RNA HOXA transcript at the distal tip promotes colorectal cancer growth partially via silencing of p21 expression.

Lian, Yifan; Ding, Jie; Zhang, Zhihong; Shi, Yongguo; Zhu, Ya; Li, Juan; Peng, Peng; Wang, Jirong; Fan, Yingrui; De, Wei; Wang, Keming

Lian, Yifan; Ding, Jie; Zhang, Zhihong; Shi, Yongguo; Zhu, Ya; Li, Juan; Peng, Peng; Wang, Jirong; Fan, Yingrui; De, Wei; Wang, Keming.

Afiliação

Lian Y; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Ding J; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Zhang Z; Departments of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Shi Y; Department of Oncology, Taixing People's Hospital, Taixing, 225400, Jiangsu, People's Republic of China.
Zhu Y; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Li J; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Peng P; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Wang J; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Fan Y; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
De W; Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
Wang K; Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China. kemingwang@njmu.edu.cn.

Tumour Biol ; 37(6): 7431-40, 2016 Jun.

Article em En | MEDLINE | ID: mdl-26678886

Assuntos

Biomarcadores Tumorais/genética; Proliferação de Células; Neoplasias Colorretais/patologia; Inibidor de Quinase Dependente de Ciclina p21/antagonistas & inibidores; Inativação Gênica; RNA Longo não Codificante/genética; RNA Interferente Pequeno/genética; Animais; Apoptose; Western Blotting; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Inibidor de Quinase Dependente de Ciclina p21/genética; Inibidor de Quinase Dependente de Ciclina p21/metabolismo; Progressão da Doença; Feminino; Citometria de Fluxo; Seguimentos; Regulação Neoplásica da Expressão Gênica; Humanos; Técnicas Imunoenzimáticas; Masculino; Camundongos; Camundongos Nus; Pessoa de Meia-Idade; Invasividade Neoplásica; Estadiamento de Neoplasias; Prognóstico; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Cell proliferation; Colorectal cancer; HOTTIP; lncRNA; p21

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Inativação Gênica / RNA Interferente Pequeno / Proliferação de Células / Inibidor de Quinase Dependente de Ciclina p21 / RNA Longo não Codificante Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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