Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner.

Wang, Tianzhen; Han, Peng; He, Yan; Zhao, Ci; Wang, Guangyu; Yang, Weiwei; Shan, Ming; Zhu, Yuanyuan; Yang, Chao; Weng, Mingjiao; Wu, Di; Gao, Lin; Jin, Xiaoming; Wei, Yunwei; Cui, BinBin; Shen, Guomin; Li, Xiaobo

Wang, Tianzhen; Han, Peng; He, Yan; Zhao, Ci; Wang, Guangyu; Yang, Weiwei; Shan, Ming; Zhu, Yuanyuan; Yang, Chao; Weng, Mingjiao; Wu, Di; Gao, Lin; Jin, Xiaoming; Wei, Yunwei; Cui, BinBin; Shen, Guomin; Li, Xiaobo.

Afiliação

Wang T; Department of Pathology, Harbin Medical University, Harbin, China.
Han P; Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
He Y; Department of Pathology, Harbin Medical University, Harbin, China.
Zhao C; Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Wang G; Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Yang W; Department of Pathology, Harbin Medical University, Harbin, China.
Shan M; Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Zhu Y; Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Yang C; Department of Pathology, Harbin Medical University, Harbin, China.
Weng M; Department of Pathology, Harbin Medical University, Harbin, China.
Wu D; Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Gao L; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
Jin X; Department of Pathology, Harbin Medical University, Harbin, China.
Wei Y; Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Cui B; Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China. 13351112888@163.com.
Shen G; Department of Medical Genetics, Medical College, Henan University of Science and Technology, Luoyang, China. shenba433@163.com.
Li X; Department of Pathology, Harbin Medical University, Harbin, China. lixiaobo@ems.hrbmu.edu.cn.

Tumour Biol ; 37(6): 7657-65, 2016 Jun.

Article em En | MEDLINE | ID: mdl-26687759

Assuntos

Adenocarcinoma/tratamento farmacológico; Antimetabólitos Antineoplásicos/farmacologia; Apoptose/genética; Neoplasias do Colo/tratamento farmacológico; Fluoruracila/farmacologia; Proteínas de Neoplasias/fisiologia; Proteínas de Ligação a RNA/fisiologia; Adenocarcinoma/genética; Adenocarcinoma/metabolismo; Adenocarcinoma/patologia; Adulto; Idoso; Apoptose/efeitos dos fármacos; Neoplasias do Colo/genética; Neoplasias do Colo/metabolismo; Neoplasias do Colo/patologia; Reparo do DNA/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos; Feminino; Células HCT116; Histonas/biossíntese; Histonas/genética; Humanos; Masculino; MicroRNAs/fisiologia; Pessoa de Meia-Idade; Proteínas de Neoplasias/biossíntese; Proteínas de Neoplasias/genética; RNA Neoplásico/fisiologia; Proteínas de Ligação a RNA/biossíntese; Proteínas de Ligação a RNA/genética; Proteínas Recombinantes de Fusão/biossíntese; Proteínas Recombinantes de Fusão/genética; Método Simples-Cego

Palavras-chave

Apoptosis; Chemosensitivity; Colon cancer; H2AX; Lin28A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Proteínas de Ligação a RNA / Apoptose / Neoplasias do Colo / Fluoruracila / Proteínas de Neoplasias / Antimetabólitos Antineoplásicos Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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