Mapping homeostatic synaptic plasticity using cable properties of dendrites.
Neuroscience
; 315: 206-16, 2016 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-26701298
ABSTRACT
When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampal neurons do not, revealing distinct homeostatic strategies between brain regions and developmental stages. The DFI presents a useful tool for mapping the dendritic origin of synaptic currents and the location of synaptic plasticity changes.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dendritos
/
Homeostase
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article