Gene co-expression networks shed light into diseases of brain iron accumulation.

Bettencourt, Conceição; Forabosco, Paola; Wiethoff, Sarah; Heidari, Moones; Johnstone, Daniel M; Botía, Juan A; Collingwood, Joanna F; Hardy, John; Milward, Elizabeth A; Ryten, Mina; Houlden, Henry

Bettencourt, Conceição; Forabosco, Paola; Wiethoff, Sarah; Heidari, Moones; Johnstone, Daniel M; Botía, Juan A; Collingwood, Joanna F; Hardy, John; Milward, Elizabeth A; Ryten, Mina; Houlden, Henry.

Afiliação

Bettencourt C; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK. Electronic address: c.bettencourt@ucl.ac.uk.
Forabosco P; Istituto di Ricerca Genetica e Biomedica CNR, Cagliari, Italy.
Wiethoff S; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Center for Neurology and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University, Tübingen, Germany.
Heidari M; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia; Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, The University of Newcastle, Callaghan, NSW, Australia.
Johnstone DM; Bosch Institute and Discipline of Physiology, University of Sydney, NSW, Australia;
Botía JA; Department of Medical and Molecular Genetics, King's College London, London, UK.
Collingwood JF; School of Engineering, University of Warwick, Coventry, UK.
Hardy J; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Milward EA; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia; Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, The University of Newcastle, Callaghan, NSW, Australia.
Ryten M; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical and Molecular Genetics, King's College London, London, UK.
Houlden H; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.

Neurobiol Dis ; 87: 59-68, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26707700

Assuntos

Gânglios da Base/metabolismo; Perfilação da Expressão Gênica/métodos; Distúrbios do Metabolismo do Ferro/metabolismo; Distrofias Neuroaxonais/metabolismo; Transcriptoma; Adolescente; Idoso; Idoso de 80 Anos ou mais; Animais; Gânglios da Base/patologia; Criança; Pré-Escolar; Modelos Animais de Doenças; Feminino; Proteína da Hemocromatose; Antígenos de Histocompatibilidade Classe I/genética; Antígenos de Histocompatibilidade Classe I/metabolismo; Humanos; Lactente; Ferro/metabolismo; Distúrbios do Metabolismo do Ferro/patologia; Masculino; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos Transgênicos; Distrofias Neuroaxonais/patologia; Neurônios/metabolismo; Neurônios/patologia; Receptores da Transferrina/genética; Receptores da Transferrina/metabolismo; Substância Branca/metabolismo; Substância Branca/patologia; Adulto Jovem

Palavras-chave

Human brain; Iron metabolism; NBIA; WGCNA; Whole-transcriptome analysis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gânglios da Base / Distrofias Neuroaxonais / Distúrbios do Metabolismo do Ferro / Perfilação da Expressão Gênica / Transcriptoma Limite: Adolescent / Adult / Aged / Aged80 / Animals / Child / Child, preschool / Female / Humans / Infant Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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