Predictors of antiretroviral therapy initiation: a cross-sectional study among Chinese HIV-infected men who have sex with men.
BMC Infect Dis
; 15: 570, 2015 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-26714889
ABSTRACT
BACKGROUND:
Early antiretroviral therapy (ART) initiation is crucial to achieve HIV viral suppression and reduce transmission. HIV-infected Chinese men who have sex with men (MSM) were less likely to initiate ART than other HIV-infected individuals. We assessed predictors of ART initiation among Chinese MSM.METHODS:
In 2010-2011, a cross-sectional study was conducted among MSM in Beijing, China. We examined ART initiation within the subgroup who were diagnosed with HIV infection prior to participation in the survey. Logistic regression models were fitted to evaluate socio-demographic and behavioral factors associated with ART initiation. The eligibility criterion in the 2010/2011 national HIV treatment guidelines was CD4 cell count <350 cells/µL or World Health Organization (WHO) clinical stage III/IV.RESULTS:
Of 238 eligible HIV-infected participants, the median duration of HIV infection was 15 months (range 31 days-12 years); 62 (26.1 %) had initiated ART. Among 103 men with CD4 counts <350 cells/µL, 38 (36.9 %) initiated ART. Being married to a woman (adjusted odd ratios [aOR] 2.50; 95 % confidence interval [CI] 1.07-5.87), longer duration of HIV infection (aOR 10.71; 95 % CI 3.66-31.32), and syphilis co-infection (aOR 2.58; 95 % CI 1.04-6.37) were associated with a higher likelihood of ART initiation. Of 135 men with CD4 count ≥350 cells/µL, 24 (18 %) initiated ART. Being married to a woman (aOR 4.21; 95 % CI 1.60-11.06), longer duration of HIV infection (aOR 22.4; 95 % CI 2.79-180), older age (aOR 1.26; 95 % CI 1.1-1.44), Beijing Hukou (aOR 4.93; 95 % CI 1.25-19.33), presence of AIDS-like clinical symptoms (aOR 3.97; 95 % CI 1.32-14.0), and history of sexually transmitted infections (aOR 4.93; 95 % CI 1.25-19.43) were associated with ART initiation. Compared with men who did not initiated ART, those with ART were more likely to receive counseling on benefits of ART (96.8 % vs. 66.4 %, P = 0 < 0.01), HIV stigma coping strategy (75.8 % vs. 65.9 %, P = 0.04), mental health (66.1 % vs. 52.9 %, P = 0.02), and substance use (46.7 % vs. 36.6 %, P = 0.04).CONCLUSIONS:
We documented low rates of ART initiation among Chinese MSM. Policy changes for expanding ART eligibility and interventions to improve the continuum of HIV care are in progress in China. Impact evaluations can help assess continuing barriers to ART initiation among MSM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Homossexualidade Masculina
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Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Etiology_studies
/
Guideline
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article