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Precision Medicine: Clarity for the Complexity of Dementia.
Cholerton, Brenna; Larson, Eric B; Quinn, Joseph F; Zabetian, Cyrus P; Mata, Ignacio F; Keene, C Dirk; Flanagan, Margaret; Crane, Paul K; Grabowski, Thomas J; Montine, Kathleen S; Montine, Thomas J.
Afiliação
  • Cholerton B; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
  • Larson EB; Group Health Research Institute, Seattle, Washington.
  • Quinn JF; Department of Neurology, Oregon Health and Science University, Portland, Oregon; Portland Veterans Affairs Medical Center, Portland, Oregon.
  • Zabetian CP; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Parkinson's Disease Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
  • Mata IF; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
  • Keene CD; Department of Pathology, University of Washington, Seattle, Washington.
  • Flanagan M; Department of Pathology, University of Washington, Seattle, Washington.
  • Crane PK; Department of Medicine, University of Washington, Seattle, Washington.
  • Grabowski TJ; Department of Neurology, University of Washington, Seattle, Washington; Department of Radiology, University of Washington, Seattle, Washington.
  • Montine KS; Department of Pathology, University of Washington, Seattle, Washington.
  • Montine TJ; Department of Pathology, University of Washington, Seattle, Washington. Electronic address: tmontine@uw.edu.
Am J Pathol ; 186(3): 500-6, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26724389
ABSTRACT
Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia Alzheimer disease and Parkinson disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Demência / Medicina de Precisão Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Demência / Medicina de Precisão Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article