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Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling.
Nagamori, Shushi; Wiriyasermkul, Pattama; Okuda, Suguru; Kojima, Naoto; Hari, Yoshiyuki; Kiyonaka, Shigeki; Mori, Yasuo; Tominaga, Hideyuki; Ohgaki, Ryuichi; Kanai, Yoshikatsu.
Afiliação
  • Nagamori S; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Wiriyasermkul P; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Okuda S; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Kojima N; Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan.
  • Hari Y; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
  • Kiyonaka S; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
  • Mori Y; Department of Technology and Ecology, Hall of Global Environmental Studies, Kyoto University, Kyoto, Japan.
  • Tominaga H; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
  • Ohgaki R; Department of Technology and Ecology, Hall of Global Environmental Studies, Kyoto University, Kyoto, Japan.
  • Kanai Y; Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan.
Amino Acids ; 48(4): 1045-1058, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26724922
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportador 1 de Aminoácidos Neutros Grandes / Proteínas Quinases S6 Ribossômicas 70-kDa / Complexos Multiproteicos / Serina-Treonina Quinases TOR / Leucina Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportador 1 de Aminoácidos Neutros Grandes / Proteínas Quinases S6 Ribossômicas 70-kDa / Complexos Multiproteicos / Serina-Treonina Quinases TOR / Leucina Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article