Calcium Signaling Is Required for Erythroid Enucleation.
PLoS One
; 11(1): e0146201, 2016.
Article
em En
| MEDLINE
| ID: mdl-26731108
ABSTRACT
Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that similar to cytokinesis, nuclear extrusion requires intracellular calcium signaling and signal transduction through the calmodulin (CaM) pathway. However, in contrast to cytokinesis we found that orthochromatic erythroblasts require uptake of extracellular calcium to enucleate. Together these functional studies highlight a critical role for calcium signaling in the regulation of erythroid enucleation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Eritroblastos
/
Sinalização do Cálcio
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article