Mismatch repair and homeologous recombination.

Tham, Khek-Chian; Kanaar, Roland; Lebbink, Joyce H G

Tham, Khek-Chian; Kanaar, Roland; Lebbink, Joyce H G.

Afiliação

Tham KC; Department of Genetics, Cancer Genomics Netherlands, Erasmus MC, Rotterdam, The Netherlands.
Kanaar R; Department of Genetics, Cancer Genomics Netherlands, Erasmus MC, Rotterdam, The Netherlands; Department of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands.
Lebbink JHG; Department of Genetics, Cancer Genomics Netherlands, Erasmus MC, Rotterdam, The Netherlands; Department of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands. Electronic address: j.lebbink@erasmusmc.nl.

DNA Repair (Amst) ; 38: 75-83, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26739221

ABSTRACT

ABSTRACT

DNA mismatch repair influences the outcome of recombination events between diverging DNA sequences. Here we discuss how mismatch repair proteins are active in different homologous recombination subpathways and specific reaction steps, resulting in differential modulation of these recombination events, with a focus on the mechanism of heteroduplex rejection during the inhibition of recombination between slightly diverged (homeologous) DNA sequences.

Assuntos

Reparo de Erro de Pareamento de DNA; Recombinação Homóloga; Animais; Replicação do DNA; Humanos; Modelos Biológicos; Ácidos Nucleicos Heteroduplexes

Palavras-chave

Antirecombination; Heteroduplex rejection; Homeologous recombination; Homologous recombination; Mismatch repair

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reparo de Erro de Pareamento de DNA / Recombinação Homóloga Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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