Investigating the state-of-the-art in whole-body MR-based attenuation correction: an intra-individual, inter-system, inventory study on three clinical PET/MR systems.
MAGMA
; 29(1): 75-87, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26739263
ABSTRACT
OBJECTIVE:
We assess inter- and intra-subject variability of magnetic resonance (MR)-based attenuation maps (MRµMaps) of human subjects for state-of-the-art positron emission tomography (PET)/MR imaging systems. MATERIALS ANDMETHODS:
Four healthy male subjects underwent repeated MR imaging with a Siemens Biograph mMR, Philips Ingenuity TF and GE SIGNA PET/MR system using product-specific MR sequences and image processing algorithms for generating MRµMaps. Total lung volumes and mean attenuation values in nine thoracic reference regions were calculated. Linear regression was used for comparing lung volumes on MRµMaps. Intra- and inter-system variability was investigated using a mixed effects model.RESULTS:
Intra-system variability was seen for the lung volume of some subjects, (p = 0.29). Mean attenuation values across subjects were significantly different (p < 0.001) due to different segmentations of the trachea. Differences in the attenuation values caused noticeable intra-individual and inter-system differences that translated into a subsequent bias of the corrected PET activity values, as verified by independent simulations.CONCLUSION:
Significant differences of MRµMaps generated for the same subjects but different PET/MR systems resulted in differences in attenuation correction factors, particularly in the thorax. These differences currently limit the quantitative use of PET/MR in multi-center imaging studies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Tomografia por Emissão de Pósitrons
/
Pulmão
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article