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Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.
Mehta, A Y; Mohammed, B M; Martin, E J; Brophy, D F; Gailani, D; Desai, U R.
Afiliação
  • Mehta AY; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA.
  • Mohammed BM; Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA.
  • Martin EJ; Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
  • Brophy DF; Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA.
  • Gailani D; Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA.
  • Desai UR; Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center, Nashville, TN, USA.
J Thromb Haemost ; 14(4): 828-38, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26748875

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Trombina / Complexo Glicoproteico GPIb-IX de Plaquetas / Anticoagulantes Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Trombina / Complexo Glicoproteico GPIb-IX de Plaquetas / Anticoagulantes Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article