Dental pulp in mature replanted human teeth: morphological alterations and metalloproteineses-2 and -9, Annexin-5, BCL-2 and iNOS modulation.
J Biol Regul Homeost Agents
; 29(4): 961-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-26753662
Tooth replantation, as a treatment concept, has been subject to controversies regarding the mechanism as well as the various parameters underlying this process. This work aimed to study time-related changes in the pulp of replanted mature human premolars through the changes in the levels of certain factors involved in the underlying mechanisms of pulpal tissue healing after replantation. Eleven experimental mature teeth were extracted, immediately replanted in the original socket and left without any other intervention for 1, 2, 3 and 12 weeks before re-extraction. Three premolars served as control. All specimens were subject to histological analysis and the levels of MMP-2, MMP-9, Annexin V, iNOS and BCL-2 (anti-apoptotic family) were analyzed employing immunohistochemistry. The results showed degradation of the extracellular matrix (ECM), inflammatory cell infiltrate, loss in pulpo-dentine interface and loss of odontoblasts in the dental pulp tissue. This was accompanied by increase over time of MMP-9, Annexin V, iNOS and a decrease of BCL-2 and MMP-2, suggesting that apoptosis increased throughout the experimental period.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reimplante Dentário
/
Anexina A5
/
Proteínas Proto-Oncogênicas c-bcl-2
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Metaloproteinase 2 da Matriz
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Metaloproteinase 9 da Matriz
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Polpa Dentária
/
Óxido Nítrico Sintase Tipo II
Limite:
Adolescent
/
Adult
/
Child
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article