Highly Stereoselective Synthesis of Imine-Containing Dibenzo[b,d]azepines by a Palladium(II)-Catalyzed [5+2] Oxidative Annulation of o-Arylanilines with Alkynes.
Angew Chem Int Ed Engl
; 54(51): 15385-9, 2015 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-26768530
ABSTRACT
A novel palladium(II)-catalyzed [5+2] oxidative annulation of readily available o-arylanilines with alkynes has been developed for building a seven-membered N-heterocyclic architecture containing a biaryl linkage. This method is applicable to a wide range of unprotected o-arylanilines and internal alkynes, and results in the chemoselective preparation of imine-containing dibenzo[b,d]azepines in high yields with excellent diastereoselectivity with respect to the two types of stereogenic elements.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2015
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Article