Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.

Wang, Shaogui; Ni, Hong-Min; Dorko, Kenneth; Kumer, Sean C; Schmitt, Timothy M; Nawabi, Atta; Komatsu, Masaaki; Huang, Heqing; Ding, Wen-Xing

Wang, Shaogui; Ni, Hong-Min; Dorko, Kenneth; Kumer, Sean C; Schmitt, Timothy M; Nawabi, Atta; Komatsu, Masaaki; Huang, Heqing; Ding, Wen-Xing.

Afiliação

Wang S; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Ni HM; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Dorko K; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Kumer SC; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Schmitt TM; Department of General Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Nawabi A; Department of General Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Komatsu M; Department of General Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Huang H; Department of Biochemistry, School of Medicine Niigata University, Chuo-ku, Niigata 951-8510, Japan.
Ding WX; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Oncotarget ; 7(14): 17681-98, 2016 Apr 05.

Article em En | MEDLINE | ID: mdl-26769846

Assuntos

Fígado Gorduroso/enzimologia; Hepatopatias Alcoólicas/enzimologia; Proteína Serina-Treonina Quinases de Interação com Receptores/biossíntese; Animais; Consumo Excessivo de Bebidas Alcoólicas/enzimologia; Consumo Excessivo de Bebidas Alcoólicas/patologia; Etanol/administração & dosagem; Proteínas Ativadoras de GTPase/biossíntese; Proteínas Ativadoras de GTPase/metabolismo; Humanos; Fígado/efeitos dos fármacos; Fígado/enzimologia; Fígado/patologia; Hepatopatias Alcoólicas/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Complexo de Proteínas Formadoras de Poros Nucleares/biossíntese; Complexo de Proteínas Formadoras de Poros Nucleares/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteínas de Ligação a RNA/biossíntese; Proteínas de Ligação a RNA/metabolismo; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo

Palavras-chave

RIP3; alcohol; liver injury; necroptosis; steatosis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Serina-Treonina Quinases de Interação com Receptores / Fígado Gorduroso / Hepatopatias Alcoólicas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google