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Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.
Han, Wooseok; Menezes, Daniel L; Xu, Yongjin; Knapp, Mark S; Elling, Robert; Burger, Matthew T; Ni, Zhi-Jie; Smith, Aaron; Lan, Jiong; Williams, Teresa E; Verhagen, Joelle; Huh, Kay; Merritt, Hanne; Chan, John; Kaufman, Susan; Voliva, Charles F; Pecchi, Sabina.
Afiliação
  • Han W; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Menezes DL; Oncology, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Xu Y; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Knapp MS; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Elling R; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Burger MT; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Ni ZJ; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Smith A; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Lan J; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Williams TE; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Verhagen J; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Huh K; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Merritt H; Oncology, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Chan J; Oncology, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Kaufman S; Oncology, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Voliva CF; Oncology, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
  • Pecchi S; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States.
Bioorg Med Chem Lett ; 26(3): 742-746, 2016 Feb 01.
Article em En | MEDLINE | ID: mdl-26774655
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article