Ki-67 antigen expression in the mammary epithelium of female rats in persistent estrus treated with raloxifene.
Eur J Gynaecol Oncol
; 36(6): 694-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-26775354
ABSTRACT
OBJECTIVE:
To evaluate Ki-67 antigen expression in the mammary epithelium of female rats in persistent estrus treated with raloxifene. MATERIALS ANDMETHODS:
Forty-one Wistar-Hannover rats in persistent estrus induced by 1.25 mg of testosterone propionate were randomly divided into two groups Group A (control, n = 21) in which the animals received only the vehicle (propylene glycol) and Group B (experimental, n = 20) in which the rats received 750 µg/day of raloxifene by gavage. After 21 days of treatment, all the animals were sacrificed and the first pair of abdominal-inguinal mammary glands was extirpated and fixed in 10% buffered formalin to investigate Ki-67 expression by immunohistochemistry. The data were analysed using Student's t-test (p < 0.05).RESULTS:
The percentage of Ki-67-stained nuclei per 500 cells in the mammary epithelium was 42.33 ± 6.18 and 15.51 ± 3.71 [mean ± standard error of the mean (SEM)] in the control and experimental groups, respectively (p < 0.001).CONCLUSION:
Raloxifene treatment significantly reduced Ki-67 expression in the mammary epithelium of rats in persistent estrus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estro
/
Antígeno Ki-67
/
Cloridrato de Raloxifeno
/
Moduladores Seletivos de Receptor Estrogênico
/
Glândulas Mamárias Animais
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article