Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate esterAZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors.
Bioorg Med Chem
; 23(24): 7521-8, 2015 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-26775541
ABSTRACT
Novel 3-hydroxy-3-phenylpropanoate ester-azidothymidine (AZT) conjugates have been prepared using Baylis-Hillman methodology, and their potential as dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors has been explored using enzyme inhibition and computer modelling techniques; their activity and HeLa cell toxicity have been compared with those of their cinnamate ester analogues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zidovudina
/
HIV-1
/
Inibidores da Transcriptase Reversa
/
Inibidores de Integrase de HIV
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article