Morphological Changes of Amygdala in Turner Syndrome Patients.
CNS Neurosci Ther
; 22(3): 194-9, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26778543
ABSTRACT
AIMS:
Turner's syndrome (TS) losts one of the X chromosomes and exhibits social cognition deficits. Previous studies have reported that women with TS demonstrated structural and functional abnormalities in brain, including increased volume in amygdala. However, most studies regarded the amygdala as a whole, and the abnormalities in the specific subregions of amygdala in TS have not been studied. Here, we aimed to investigate the local morphological changes of amygdala in TS using the surface morphology analysis method.METHODS:
A total of 19 adolescents with 45XO TS and 20 matched adolescents with typical development were evaluated using magnetic resonance imaging. The amygdalae of all participants were manually delineated. 3D surface remodeling and parameterization were performed based on the outlined boundaries of amygdalae. We extracted two surface metrics, namely direct Euclidean displacement and normal projection that were used to represent the morphology of amygdala.RESULTS:
Statistical analysis showed significant outward deformation in the laterobasal subregion of left amygdala in patients with TS, compared with the controls using either direct Euclidean displacement or normal displacement.CONCLUSIONS:
Our findings provide novel insight into the pathological changes in the amygdala of patients with TS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Turner
/
Tonsila do Cerebelo
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article