TRANS PROF DB: A new resource for sharing translational profiles.

ABSTRACT

The translational efficiency of individual mRNAs can be measured on a genome-wide scale using translational profiling techniques. Data from such experiments are an enormously important resource in the quest to understand the impact of cellular state on gene expression. To improve our understanding of these data, we have created TRANS PROF DB, a manually curated resource containing the translational status of human mRNAs under defined conditions. Results are provided at the level of an annotated conclusion for each gene, e.g. "Translation up-regulated", and also, where available, in a rawer form such as the normalized analyzed microarray output. TRANS PROF DB aims to provide a central resource for the sharing of translational profiles to facilitate reuse of published data and to enable meta-analyses across data sets. As the database expands, it will provide an easily searchable archive of publicly available translational profiling data sets. We encourage all researchers to deposit their translational profiling data into TRANS PROF DB to enable us to create a truly comprehensive resource. TRANS PROF DB is available without restriction at mrctools.mrctox.le.ac.uk/TRANS_PROF_DB.