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Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Drinkwater, Nyssa; Vinh, Natalie B; Mistry, Shailesh N; Bamert, Rebecca S; Ruggeri, Chiara; Holleran, John P; Loganathan, Sasdekumar; Paiardini, Alessandro; Charman, Susan A; Powell, Andrew K; Avery, Vicky M; McGowan, Sheena; Scammells, Peter J.
Afiliação
  • Drinkwater N; Biomedicine Discovery Institute and Department of Microbiology, Melbourne, VIC 3800, Australia; Department of Biochemistry and Molecular Biology Monash University (Clayton Campus), Melbourne, VIC 3800, Australia.
  • Vinh NB; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia.
  • Mistry SN; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia.
  • Bamert RS; Biomedicine Discovery Institute and Department of Microbiology, Melbourne, VIC 3800, Australia; Department of Biochemistry and Molecular Biology Monash University (Clayton Campus), Melbourne, VIC 3800, Australia.
  • Ruggeri C; Dipartmento di Biologia e Biotecnologie "Charles Darwin", Sapienza Universita di Roma, 00185 Roma, Italy.
  • Holleran JP; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.
  • Loganathan S; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.
  • Paiardini A; Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, 00185 Roma, Italy.
  • Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia.
  • Powell AK; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia.
  • Avery VM; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.
  • McGowan S; Biomedicine Discovery Institute and Department of Microbiology, Melbourne, VIC 3800, Australia; Department of Biochemistry and Molecular Biology Monash University (Clayton Campus), Melbourne, VIC 3800, Australia. Electronic address: Sheena.McGowan@monash.edu.
  • Scammells PJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia. Electronic address: Peter.Scammells@monash.edu.
Eur J Med Chem ; 110: 43-64, 2016 Mar 03.
Article em En | MEDLINE | ID: mdl-26807544
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Inibidores de Proteases / Proteínas de Protozoários / Aminopeptidases / Ácidos Hidroxâmicos / Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Inibidores de Proteases / Proteínas de Protozoários / Aminopeptidases / Ácidos Hidroxâmicos / Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article