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[Renal hypophosphatemia:pathophysiology and treatment].
Sekine, Takashi.
Afiliação
  • Sekine T; Department of Pediatrics, Toho University Ohashi Hospital, Japan.
Clin Calcium ; 26(2): 284-94, 2016 Feb.
Article em Ja | MEDLINE | ID: mdl-26813509
Serum level of phosphate is regulated by the kidney, especially proximal tubule. The transcellular transport of phosphate in the proximal tubule is mediated via Na dependent transporters, i.e., NPT2a and NPT2b at the luminal membrane, and unknown channel at the basolateral side. The transport of phosphate via NPT2a and NPT2b is further regulated by factors, such as PTH, FGF23, and 1,25(OH)(2)D. Several hereditary diseases that cause hypophoshatemia specically are known. In addition, dysfunction of proximal tubule may develop Fanconi syndrome, which also causes hypherphosphaturia. In this section, I describe the renal mechanisms of phosphate handling and the causes of hypophosphatemia along with its treatment.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Hipofosfatemia / Túbulos Renais Proximais Tipo de estudo: Etiology_studies Limite: Humans Idioma: Ja Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Hipofosfatemia / Túbulos Renais Proximais Tipo de estudo: Etiology_studies Limite: Humans Idioma: Ja Ano de publicação: 2016 Tipo de documento: Article