Effects of osteoformin in the rapid distraction osteogenesis of rabbit mandibles.
J Pak Med Assoc
; 66(2): 135-9, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26819154
ABSTRACT
OBJECTIVE:
To evaluate the effects of osteoformin on mineralisation and quality of the new bone formation during rapid distraction osteogenesis.METHODS:
This multi-centre study was conducted at the Karadeniz Technical University, Middle East Technical University and Selcuk University. The experimental study was conducted from January 2010 to September 2012 and comprised New-Zealand rabbits that were randomly divided into three groups. In group I distraction rate was 1 mm/day while in groups II and III distraction rates were 2mm/day and 1 mm/day. In groups I and II 100µg/kg osteoformin was injected after the latency period. Distraction region was evaluated by radiological, histomorphometrical and dual energy X-ray absorptiometry analyses. SPSS 17 was used for statistical analysis.RESULTS:
There were 18 rabbits with each of three groups having 6(33.3%). Accelerated bone healing was noted in groups I and II compared with group III (p<0.05). No significant differences were indicated between groups I and II (p>0.05).CONCLUSIONS:
Local injection of osteoformin was effective in the craniomaxillofacial distraction osteogenesis in rabbits. Further experimental studies are recommended before using osteoformin on humans.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Regeneração Óssea
/
Consolidação da Fratura
/
Osteogênese por Distração
/
Mandíbula
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article