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Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics.
Xie, Deyao; Wu, Xiaoyi; Lan, Linhua; Shangguan, Fugeng; Lin, Xiaoming; Chen, Fuhong; Xu, Shan; Zhang, Ya; Chen, Zilei; Huang, Kate; Wang, Rongrong; Wang, Lu; Song, Xiaoxiao; Liu, Yongzhang; Lu, Bin.
Afiliação
  • Xie D; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Wu X; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Lan L; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Shangguan F; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Lin X; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Chen F; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Xu S; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Zhang Y; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Chen Z; Huzhou Health School, Huzhou, Zhejiang 313100, P.R. China.
  • Huang K; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Wang R; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Wang L; Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Song X; Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Liu Y; Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
  • Lu B; Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.
Oncotarget ; 7(10): 11609-24, 2016 Mar 08.
Article em En | MEDLINE | ID: mdl-26820294
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Espécies Reativas de Oxigênio / Carcinoma Pulmonar de Células não Pequenas / Sistema de Sinalização das MAP Quinases / Proteínas Mitocondriais / Proteínas Quinases JNK Ativadas por Mitógeno / Proteínas de Ligação a DNA / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Espécies Reativas de Oxigênio / Carcinoma Pulmonar de Células não Pequenas / Sistema de Sinalização das MAP Quinases / Proteínas Mitocondriais / Proteínas Quinases JNK Ativadas por Mitógeno / Proteínas de Ligação a DNA / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article