Integrating biophysics with HTS-driven drug discovery projects.
Drug Discov Today
; 21(3): 491-8, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26826422
ABSTRACT
Over the past decade biophysics has become an established discipline in HTS hit triaging, owing to its high fidelity in detecting protein-ligand interactions. Many pharma companies are using biophysical techniques to filter HTS output for false positives, as will be discussed in this review. Moreover, I will demonstrate how the earlier application of biophysics, already at the HTS assay development stage, is potentially even more impactful. Two key areas here are early mode-of-action studies and ensuring that the HTS assay and subsequent cascade are fit for purpose. Top-level results from 20 in-house projects are shown to underpin the impact of these studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Descoberta de Drogas
/
Fenômenos Biofísicos
/
Ensaios de Triagem em Larga Escala
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article