Evaluating the safety and efficacy of felbamate in the context of a black box warning: A single center experience.
Epilepsy Behav
; 56: 50-3, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26828692
ABSTRACT
INTRODUCTION:
Felbamate was approved in 1993 to treat partial seizures with and without secondary generalization in adults and in Lennox-Gastaut Syndrome in children. Its use was later restricted when rare but fatal cases of aplastic anemia and hepatic failure were identified.METHODS:
This single center analysis retrospectively evaluated the safety and efficacy of felbamate in a cohort of children, adolescents, and adults with epilepsy.RESULTS:
A chart review identified 103 patients taking felbamate. The range of felbamate dose was 300-4500 mg (mean 1800 ± 900 mg). The duration of therapy ranged from 1 month to 20 years (mean duration 35 ± 45 months). Eighteen (17.5%) subjects experienced adverse events including insomnia, nausea, vomiting, decreased appetite, weight loss, gastric discomfort, diarrhea, mood and behavioral problems, high blood pressure, headache, and elevated liver enzymes. Out of these, 6 (5.9%) patients discontinued the therapy. No hepatic failure or agranulocytosis was observed. Fifty-nine (57.72%) patients achieved ≥ 50% reduction in seizure frequency, and 30 (29.12%) patients achieved seizure freedom.CONCLUSIONS:
These findings suggest that felbamate is safe, well tolerated, and effective in treatment of various types of epilepsy syndromes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propilenoglicóis
/
Convulsões
/
Fenilcarbamatos
/
Epilepsia
/
Anticonvulsivantes
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article