5-Azacytidine Enhances the Mutagenesis of HIV-1 by Reduction to 5-Aza-2'-Deoxycytidine.

Rawson, Jonathan M O; Daly, Michele B; Xie, Jiashu; Clouser, Christine L; Landman, Sean R; Reilly, Cavan S; Bonnac, Laurent; Kim, Baek; Patterson, Steven E; Mansky, Louis M

Rawson, Jonathan M O; Daly, Michele B; Xie, Jiashu; Clouser, Christine L; Landman, Sean R; Reilly, Cavan S; Bonnac, Laurent; Kim, Baek; Patterson, Steven E; Mansky, Louis M.

Afiliação

Rawson JM; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA Molecular, Cellular, Developmental Biology and Genetics Graduate Program, University of Minnesota, Minneapolis, Minnesota, USA.
Daly MB; Center for Drug Discovery, Department of Pediatrics, Emory Center for AIDS Research, Emory University, Atlanta, Georgia, USA.
Xie J; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota, USA.
Clouser CL; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
Landman SR; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Reilly CS; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Bonnac L; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota, USA.
Kim B; Center for Drug Discovery, Department of Pediatrics, Emory Center for AIDS Research, Emory University, Atlanta, Georgia, USA.
Patterson SE; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota, USA.
Mansky LM; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, USA Molecula

Antimicrob Agents Chemother ; 60(4): 2318-25, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26833151

Assuntos

Fármacos Anti-HIV/farmacologia; Azacitidina/análogos & derivados; Azacitidina/farmacologia; DNA Viral/metabolismo; HIV-1/efeitos dos fármacos; Mutagênese/efeitos dos fármacos; Inibidores da Transcriptase Reversa/farmacologia; Fármacos Anti-HIV/metabolismo; Azacitidina/metabolismo; Cromatografia Líquida; Citidina Trifosfato/análogos & derivados; Citidina Trifosfato/metabolismo; DNA Viral/genética; Decitabina; Células HEK293; Transcriptase Reversa do HIV/antagonistas & inibidores; Transcriptase Reversa do HIV/genética; Transcriptase Reversa do HIV/metabolismo; HIV-1/genética; HIV-1/metabolismo; Humanos; Oxirredução; Provírus/efeitos dos fármacos; Provírus/genética; Provírus/metabolismo; Inibidores da Transcriptase Reversa/metabolismo; Transcrição Reversa/efeitos dos fármacos; Ribonucleotídeo Redutases/genética; Ribonucleotídeo Redutases/metabolismo; Análise de Sequência de DNA; Espectrometria de Massas em Tandem

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azacitidina / DNA Viral / Mutagênese / HIV-1 / Inibidores da Transcriptase Reversa / Fármacos Anti-HIV Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google