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The cost of managing severe hypoglycemic episodes in Type 2 diabetic patients.
Laires, Pedro Almeida; Conceição, João; Araújo, Francisco; Dores, Jorge; Silva, Catarina; Radican, Larry; Nogueira, Ana.
Afiliação
  • Laires PA; a 1 Merck Sharp & Dohme, Qta. da Fonte 19, 2770-192 Paço de Arcos, Portugal.
  • Conceição J; a 1 Merck Sharp & Dohme, Qta. da Fonte 19, 2770-192 Paço de Arcos, Portugal.
  • Araújo F; b 2 Hospital Beatriz Ângelo, Lisbon, Portugal.
  • Dores J; c 3 Hospital Santo António, Porto, Portugal.
  • Silva C; d 4 Eurotrials, Scientific Consultants S.A, Lisbon, Portugal.
  • Radican L; e 5 Merck Sharp & Dome, NJ, USA.
  • Nogueira A; a 1 Merck Sharp & Dohme, Qta. da Fonte 19, 2770-192 Paço de Arcos, Portugal.
Article em En | MEDLINE | ID: mdl-26844705
INTRODUCTION: Hypoglycemia is an acute complication of diabetes that increases morbidity, mortality and disease costs. We aim to estimate healthcare resource consumption and costs associated with severe hypoglycemia using the societal perspective. METHODS: A cross-sectional, observational, nationwide, multicenter, hospital-based study was conducted in seven centers of Portuguese mainland with a 1-year enrolment period. Unit costs were extracted from official/public data sources. Patient-level data were used to quantify healthcare resource use related to emergency transportation, emergency-department care and hospitalization. Productivity loss was calculated based on the Human Capital Approach. RESULTS: The study enrolled 238 Type-2 diabetic patients and the proportion of hypoglycemic episodes among all emergency events during the study period was 0.075% (95% CI: 0.067-0.083%). Mean patient age was 76 years and 57.6% were female. At time of the emergency department admission, 55% of patients were using insulin, 31.5% were being treated with secretagogues, 6.7% were on a combination of both, and 6.7% were on other oral antihyperglycemic agents. Estimated mean costs in the emergency department were: emergency transportation €33, medication €4, laboratory workup €56, other exams €72, physician and nurse time €30 and €13, respectively. Mean hospitalization cost was €1271. Indirect cost averaged €15. Overall cost per hypoglycemic episode averaged €1493 (standard deviation: €2962; range: €34-26,818). Patients treated with secretagogues had the highest rates of hospitalizations and mean costs. CONCLUSION: We conclude that severe hypoglycemic events represent a substantial cost for society and in particular for the hospitals of the National Health Service.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Hipoglicemia / Hipoglicemiantes Tipo de estudo: Clinical_trials / Health_economic_evaluation / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Hipoglicemia / Hipoglicemiantes Tipo de estudo: Clinical_trials / Health_economic_evaluation / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article